{"id":3755,"date":"2024-06-03T14:18:21","date_gmt":"2024-06-03T06:18:21","guid":{"rendered":"https:\/\/www.360mdi.com\/archives\/3755"},"modified":"2024-06-03T14:18:21","modified_gmt":"2024-06-03T06:18:21","slug":"25-%e4%ba%8c%e7%94%b2%e5%9f%ba%e8%8b%af%e8%83%ba","status":"publish","type":"post","link":"https:\/\/www.360mdi.com\/archives\/3755","title":{"rendered":"2,5-\u4e8c\u7532\u57fa\u80fa"},"content":{"rendered":"<p>    \t\t\t\t\t\t<img decoding=\"async\" src=\"http:\/\/staticv5.basechem.org\/img\/tupu\/old\/7903a7497ea64bda881be71e9258cc14.gif\" alt=\"2,5-\u4e8c\u7532\u57fa\u80fa\u7ed3\u6784\u5f0f\"><\/p>\n<p>\u7ed3\u6784\u5f0f<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">\u7269\u7ade\u7f16\u53f7<\/th>\n<td>029U<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u5206\u5b50\u5f0f<\/th>\n<td>C8H11N<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u5206\u5b50\u91cf<\/th>\n<td>121.18<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u6807\u7b7e<\/th>\n<td>\n<p>                        1-\u6c28\u57fa-2,5-,<\/p>\n<p>                        \u5bf9\u4e8c\u7532\u57fa\u80fa,<\/p>\n<p>                        2,5-Dimethylaniline,<\/p>\n<p>                        1-Amino-2,5-dimethylbenzene,<\/p>\n<p>                        2,5-Dimethylbenzenamine<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">\u7f16\u53f7\u7cfb\u7edf<\/a><\/li>\n<li><a href=\"#wx\">\u7269\u6027\u6570\u636e<\/a><\/li>\n<li><a href=\"#dl\">\u6bd2\u7406\u5b66\u6570\u636e<\/a><\/li>\n<li><a href=\"#st\">\u751f\u6001\u5b66\u6570\u636e<\/a><\/li>\n<li><a href=\"#fz\">\u5206\u5b50\u7ed3\u6784\u6570\u636e<\/a><\/li>\n<li><a href=\"#js\">\u8ba1\u7b97\u5316\u5b66\u6570\u636e<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                    <a href=\"\" class=\"dropdown-toggle\" data-toggle=\"dropdown\">\u66f4\u591a <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">\u6027\u8d28\u4e0e\u7a33\u5b9a\u6027<\/a><\/li>\n<li><a href=\"#zc\">\u8d2e\u5b58\u65b9\u6cd5<\/a><\/li>\n<li><a href=\"#hc\">\u5408\u6210\u65b9\u6cd5<\/a><\/li>\n<li><a href=\"#yt\">\u7528\u9014<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">\u7f16\u53f7\u7cfb\u7edf<\/h2>\n<p><b>CAS\u53f7\uff1a<\/b>95-78-3<\/p>\n<p><b>MDL\u53f7\uff1a<\/b>MFCD00007743<\/p>\n<p><b>EINECS\u53f7\uff1a<\/b>202-451-0<\/p>\n<p><b>RTECS\u53f7\uff1a<\/b>ZE9100000<\/p>\n<p><b>BRN\u53f7\uff1a<\/b>2205178<\/p>\n<p><b>PubChem\u53f7\uff1a<\/b>24846569<\/p>\n<h2 id=\"wx\">\u7269\u6027\u6570\u636e<\/h2>\n<p><p>1.\u6027\u72b6\uff1a\u65e0\u8272\u6216\u6de1\u9ec4\u8272\u6cb9\u72b6\u6db2\u4f53\uff0c\u4f4e\u6e29\u65f6\u5f62\u6210\u7ed3\u6676\u3002<sup>[1]<\/sup><\/p>\n<p>2.\u7194\u70b9\uff08\u2103\uff09\uff1a15.5<sup>[2]<\/sup><\/p>\n<p>3.\u6cb8\u70b9\uff08\u2103\uff09\uff1a214~217<sup>[3]<\/sup><\/p>\n<p>4.\u76f8\u5bf9\u5bc6\u5ea6\uff08\u6c34=1\uff09\uff1a0.98<sup>[4]<\/sup><\/p>\n<p>5.\u76f8\u5bf9\u84b8\u6c14\u5bc6\u5ea6\uff08\u7a7a\u6c14=1\uff09\uff1a4.18<sup>[5]<\/sup><\/p>\n<p>6.\u9971\u548c\u84b8\u6c14\u538b\uff08kPa\uff09\uff1a1.33\uff0897\u2103\uff09<sup>[6]<\/sup><\/p>\n<p>7.\u8f9b\u9187\/\u6c34\u5206\u914d\u7cfb\u6570\uff1a1.83~2.21<sup>[7]<\/sup><\/p>\n<p>8.\u95ea\u70b9\uff08\u2103\uff09\uff1a93.89<sup>[8]<\/sup><\/p>\n<p>9.\u7206\u70b8\u4e0a\u9650\uff08%\uff09\uff1a\u6682\u65e0\u8d44\u6599<\/p>\n<p>10.\u7206\u70b8\u4e0b\u9650\uff08%\uff09\uff1a1.5<sup>[9]<\/sup><\/p>\n<p>11.\u6eb6\u89e3\u6027\uff1a\u4e0d\u6eb6\u4e8e\u6c34\uff0c\u5fae\u6eb6\u4e8e\u9187\uff0c\u6eb6\u4e8e\u3001\u6c2f\u4eff\u3002<sup>[10]<\/sup><\/p>\n<\/p>\n<h2 id=\"dl\">\u6bd2\u7406\u5b66\u6570\u636e<\/h2>\n<p><p>1\u3001\u6025\u6027\u6bd2\u6027\uff1a\u5927\u9f20\u7ecf\u53e3LD50\uff1a1297mg\/kg\uff1b\u5c0f\u9f20\u7ecf\u53e3LD50\uff1a841mg\/kg\uff1b<\/p>\n<p>2\u3001\u5176\u4ed6\u591a\u5242\u91cf\u6bd2\u6027\uff1a\u5927\u9f20\u7ecf\u53e3TDLo\uff1a13300mg\/kg\/4W-I\uff1b<\/p>\n<p>3\u3001\u81f4\u7a81\u53d8\u6027<\/p>\n<p>\u5fae\u751f\u7269\u9f20\u4f24\u5bd2\u6c99\u95e8\u6c0f\u83cc\u7a81\u53d8\uff1a10\u03bcmol\/plate\uff1b<\/p>\n<p>\u5927\u9f20\u809d\u7684DNA\u5408\u6210\uff1a10\u03bcmol\/L\uff1b<\/p>\n<p>\u5c0f\u9f20\u7ecf\u53e3\u7684DNA\u6291\u5236\uff1a200 mg\/kg\uff1b<\/p>\n<p><strong>4.\u6025\u6027\u6bd2\u6027<sup>[11] <\/sup>&nbsp;&nbsp;<\/strong>LD50\uff1a1120mg\/kg\uff08\u5927\u9f20\u7ecf\u53e3\uff09<strong><\/strong><\/p>\n<p><strong>5.\u523a\u6fc0\u6027<\/strong>&nbsp; \u6682\u65e0\u8d44\u6599<\/p>\n<\/p>\n<h2 id=\"st\">\u751f\u6001\u5b66\u6570\u636e<\/h2>\n<p><p><strong>1.\u751f\u6001\u6bd2\u6027<sup>[12]<\/sup><\/strong> &nbsp;&nbsp;IC50\uff1a5mg\/L\uff0872h\uff09\uff08\u85fb\u7c7b\uff09<\/p>\n<p><strong>2.\u751f\u7269\u964d\u89e3\u6027<\/strong>&nbsp; \u6682\u65e0\u8d44\u6599<\/p>\n<p><strong>3.\u975e\u751f\u7269\u964d\u89e3\u6027<sup>[13]<\/sup>&nbsp;&nbsp; <\/strong>\u7a7a\u6c14\u4e2d\uff0c\u5f53\u7f9f\u57fa\u81ea\u7531\u57fa\u6d53\u5ea6\u4e3a5.00\u00d710<sup>5<\/sup>\u4e2a\/cm<sup>3<\/sup>\u65f6\uff0c\u964d\u89e3\u534a\u8870\u671f\u4e3a2h\uff08\u7406\u8bba\uff09\u3002<\/p>\n<p><strong>4.\u5176\u4ed6\u6709\u5bb3\u4f5c\u7528<sup>[14]<\/sup><\/strong>&nbsp; \u8be5\u7269\u8d28\u5bf9\u73af\u5883\u6709\u5371\u5bb3\uff0c\u5e94\u7279\u522b\u6ce8\u610f\u5bf9\u6c34\u4f53\u7684\u6c61\u67d3\u3002<\/p>\n<\/p>\n<h2 id=\"fz\">\u5206\u5b50\u7ed3\u6784\u6570\u636e<\/h2>\n<p><p>1\u3001\u6469\u5c14\u6298\u5c04\u7387\uff1a40.20<\/p>\n<p>2\u3001\u6469\u5c14\u4f53\u79ef\uff08cm<sup>3<\/sup>\/mol\uff09\uff1a119.9<\/p>\n<p>3\u3001\u7b49\u5f20\u6bd4\u5bb9\uff0890.2K\uff09\uff1a306.6<\/p>\n<p>4\u3001\u8868\u9762\u5f20\u529b\uff08dyne\/cm\uff09\uff1a42.7<\/p>\n<p>5\u3001\u6781\u5316\u7387\uff0810-24cm3\uff09\uff1a15.94<\/p>\n<\/p>\n<h2 id=\"js\">\u8ba1\u7b97\u5316\u5b66\u6570\u636e<\/h2>\n<p><p>1.\u758f\u6c34\u53c2\u6570\u8ba1\u7b97\u53c2\u8003\u503c\uff08XlogP\uff09:\u65e0<\/P><\/p>\n<p>2.\u6c22\u952e\u4f9b\u4f53\u6570\u91cf:1<\/p>\n<p>3.\u6c22\u952e\u53d7\u4f53\u6570\u91cf:1<\/p>\n<p>4.\u53ef\u65cb\u8f6c\u5316\u5b66\u952e\u6570\u91cf:0<\/p>\n<p>5.\u4e92\u53d8\u5f02\u6784\u4f53\u6570\u91cf:\u65e0<\/p>\n<p>6.\u62d3\u6251\u5206\u5b50\u6781\u6027\u8868\u9762\u79ef26<\/p>\n<p>7.\u91cd\u539f\u5b50\u6570\u91cf:9<\/p>\n<p>8.\u8868\u9762\u7535\u8377:0<\/p>\n<p>9.\u590d\u6742\u5ea6:90.6<\/p>\n<p>10.\u540c\u4f4d\u7d20\u539f\u5b50\u6570\u91cf:0<\/p>\n<p>11.\u786e\u5b9a\u539f\u5b50\u7acb\u6784\u4e2d\u5fc3\u6570\u91cf:0<\/p>\n<p>12.\u4e0d\u786e\u5b9a\u539f\u5b50\u7acb\u6784\u4e2d\u5fc3\u6570\u91cf:0<\/p>\n<p>13.\u786e\u5b9a\u5316\u5b66\u952e\u7acb\u6784\u4e2d\u5fc3\u6570\u91cf:0<\/p>\n<p>14.\u4e0d\u786e\u5b9a\u5316\u5b66\u952e\u7acb\u6784\u4e2d\u5fc3\u6570\u91cf:0<\/p>\n<p>15.\u5171\u4ef7\u952e\u5355\u5143\u6570\u91cf:1<\/p>\n<\/p>\n<h2 id=\"xz\">\u6027\u8d28\u4e0e\u7a33\u5b9a\u6027<\/h2>\n<p><p>1.\u5728\u5149\u548c\u7a7a\u6c14\u4e2d\u989c\u8272\u9010\u6e10\u53d8\u6df1\u3002\u80fd\u968f\u84b8\u6c7d\u4e00\u540c\u6325\u53d1\u3002<\/p>\n<p><strong>2.\u7a33\u5b9a\u6027<sup>[15]<\/sup><\/strong>&nbsp; \u7a33\u5b9a<\/p>\n<p><strong>3.\u7981\u914d\u7269<sup>[16]<\/sup><\/strong>&nbsp; \u9178\u7c7b\u3001\u9170\u57fa\u6c2f\u3001\u9178\u9150\u3001\u5f3a\u6c27\u5316\u5242\u3001\u6c2f\u4eff\u3001\u5364\u7d20<\/p>\n<p><strong>4.\u907f\u514d\u63a5\u89e6\u7684\u6761\u4ef6<sup>[17]<\/sup><\/strong>&nbsp; \u53d7\u70ed<\/p>\n<p><strong>5.\u805a\u5408\u5371\u5bb3<sup>[18]<\/sup><\/strong>&nbsp; \u4e0d\u805a\u5408<\/p>\n<\/p>\n<h2 id=\"zc\">\u8d2e\u5b58\u65b9\u6cd5<\/h2>\n<p><p><strong>\u50a8\u5b58\u6ce8\u610f\u4e8b\u9879<sup>[19]<\/sup><\/strong> \u50a8\u5b58\u4e8e\u9634\u51c9\u3001\u901a\u98ce\u7684\u5e93\u623f\u3002\u8fdc\u79bb\u706b\u79cd\u3001\u70ed\u6e90\u3002\u4fdd\u6301\u5bb9\u5668\u5bc6\u5c01\u3002\u5e94\u4e0e\u6c27\u5316\u5242\u3001\u9178\u7c7b\u3001\u5364\u7d20\u3001\u98df\u7528\u5316\u5b66\u54c1\u5206\u5f00\u5b58\u653e\uff0c\u5207\u5fcc\u6df7\u50a8\u3002\u914d\u5907\u76f8\u5e94\u54c1\u79cd\u548c\u6570\u91cf\u7684\u6d88\u9632\u5668\u6750\u3002\u50a8\u533a\u5e94\u5907\u6709\u6cc4\u6f0f\u5e94\u6025\u5904\u7406\u8bbe\u5907\u548c\u5408\u9002\u7684\u6536\u5bb9\u6750\u6599\u3002<\/p>\n<\/p>\n<h2 id=\"hc\">\u5408\u6210\u65b9\u6cd5<\/h2>\n<p><p>\u7531\u5bf9\u7ecf\u785d\u5316\u548c\u8fd8\u539f\u5236\u5f97\u3002<\/p>\n<\/p>\n<h2 id=\"yt\">\u7528\u9014<\/h2>\n<p><p>1.\u7528\u4e8e\u5236\u836f\u53ca\u67d3\u6599\u5de5\u4e1a\u3002<sup>[20]<\/sup><\/p>\n<\/p>\n<p>    \t\u6269\u5c55\u9605\u8bfb<a href=\"https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/124-2.jpg\">https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/124-2.jpg<\/a><\/br>\u6269\u5c55\u9605\u8bfb<a href=\"https:\/\/www.cyclohexylamine.net\/dibutyltin-oxide-cas-818-08-6\/\">https:\/\/www.cyclohexylamine.net\/dibutyltin-oxide-cas-818-08-6\/<\/a><\/br>\u6269\u5c55\u9605\u8bfb<a href=\"https:\/\/www.newtopchem.com\/archives\/44462\">https:\/\/www.newtopchem.com\/archives\/44462<\/a><\/br>\u6269\u5c55\u9605\u8bfb<a href=\"https:\/\/www.cyclohexylamine.net\/nn-dimethylcyclohexylamine-cas-98-94-2-polycat-8\/\">https:\/\/www.cyclohexylamine.net\/nn-dimethylcyclohexylamine-cas-98-94-2-polycat-8\/<\/a><\/br>\u6269\u5c55\u9605\u8bfb<a href=\"https:\/\/www.bdmaee.net\/di-n-octyltin-oxide-2\/\">https:\/\/www.bdmaee.net\/di-n-octyltin-oxide-2\/<\/a><\/br>\u6269\u5c55\u9605\u8bfb<a href=\"https:\/\/www.newtopchem.com\/archives\/45149\">https:\/\/www.newtopchem.com\/archives\/45149<\/a><\/br>\u6269\u5c55\u9605\u8bfb<a href=\"https:\/\/www.bdmaee.net\/lupragen-n106-strong-foaming-catalyst-di-morpholine-diethyl-ether-basf\/\">https:\/\/www.bdmaee.net\/lupragen-n106-strong-foaming-catalyst-di-morpholine-diethyl-ether-basf\/<\/a><\/br>\u6269\u5c55\u9605\u8bfb<a href=\"https:\/\/www.newtopchem.com\/archives\/545\">https:\/\/www.newtopchem.com\/archives\/545<\/a><\/br>\u6269\u5c55\u9605\u8bfb<a href=\"https:\/\/www.cyclohexylamine.net\/dibutyltin-dilaurate-cas-77-58-7\/\">https:\/\/www.cyclohexylamine.net\/dibutyltin-dilaurate-cas-77-58-7\/<\/a><\/br>\u6269\u5c55\u9605\u8bfb<a href=\"https:\/\/www.bdmaee.net\/wp-content\/uploads\/2020\/06\/72.jpg\">https:\/\/www.bdmaee.net\/wp-content\/uploads\/2020\/06\/72.jpg<\/a><\/br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7ed3\u6784\u5f0f \u7269\u7ade\u7f16\u53f7 029U \u5206\u5b50\u5f0f C8H11N \u5206\u5b50\u91cf 121.18 \u6807\u7b7e 1-\u6c28\u57fa-2,5-, \u5bf9\u4e8c\u7532\u57fa\u80fa, 2,5-Dimethylaniline, 1-Amino-2,5-dimethylbenzene, 2,5-Dimethylbenzenamine \u7f16\u53f7\u7cfb\u7edf \u7269\u6027\u6570\u636e \u6bd2\u7406\u5b66\u6570\u636e \u751f\u6001\u5b66\u6570\u636e \u5206\u5b50\u7ed3\u6784\u6570\u636e \u8ba1\u7b97\u5316\u5b66\u6570\u636e \u66f4\u591a \u6027\u8d28\u4e0e\u7a33\u5b9a\u6027 \u8d2e\u5b58\u65b9\u6cd5 \u5408\u6210\u65b9\u6cd5 \u7528\u9014 \u7f16\u53f7\u7cfb\u7edf CAS\u53f7\uff1a95-78-3 MDL\u53f7\uff1aMFCD00007743 EINECS\u53f7\uff1a202-451-0 RTECS\u53f7\uff1aZE9100000 BRN\u53f7\uff1a2205178 PubChem\u53f7\uff1a24846569 \u7269\u6027\u6570\u636e 1.\u6027\u72b6\uff1a\u65e0\u8272\u6216\u6de1\u9ec4\u8272\u6cb9\u72b6\u6db2\u4f53\uff0c\u4f4e\u6e29\u65f6\u5f62\u6210\u7ed3\u6676\u3002[1] 2.\u7194\u70b9\uff08\u2103\uff09\uff1a15.5[2] 3.\u6cb8\u70b9\uff08\u2103\uff09\uff1a214~217[3] 4.\u76f8\u5bf9\u5bc6\u5ea6\uff08\u6c34=1\uff09\uff1a0.98[4] 5.\u76f8\u5bf9\u84b8\u6c14\u5bc6\u5ea6\uff08\u7a7a\u6c14=1\uff09\uff1a4.18[5] 6.\u9971\u548c\u84b8\u6c14\u538b\uff08kPa\uff09\uff1a1.33\uff0897\u2103\uff09[6] 7.\u8f9b\u9187\/\u6c34\u5206\u914d\u7cfb\u6570\uff1a1.83~2.21[7] 8.\u95ea\u70b9\uff08\u2103\uff09\uff1a93.89[8] 9.\u7206\u70b8\u4e0a\u9650\uff08%\uff09\uff1a\u6682\u65e0\u8d44\u6599 10.\u7206\u70b8\u4e0b\u9650\uff08%\uff09\uff1a1.5[9] 11.\u6eb6\u89e3\u6027\uff1a\u4e0d\u6eb6\u4e8e\u6c34\uff0c\u5fae\u6eb6\u4e8e\u9187\uff0c\u6eb6\u4e8e\u3001\u6c2f\u4eff\u3002[10] \u6bd2\u7406\u5b66\u6570\u636e 1\u3001\u6025\u6027\u6bd2\u6027\uff1a\u5927\u9f20\u7ecf\u53e3LD50\uff1a1297mg\/kg\uff1b\u5c0f\u9f20\u7ecf\u53e3LD50\uff1a841mg\/kg\uff1b 2\u3001\u5176\u4ed6\u591a\u5242\u91cf\u6bd2\u6027\uff1a\u5927\u9f20\u7ecf\u53e3TDLo\uff1a13300mg\/kg\/4W-I\uff1b 3\u3001\u81f4\u7a81\u53d8\u6027 \u5fae\u751f\u7269\u9f20\u4f24\u5bd2\u6c99\u95e8\u6c0f\u83cc\u7a81\u53d8\uff1a10\u03bcmol\/plate\uff1b \u5927\u9f20\u809d\u7684DNA\u5408\u6210\uff1a10\u03bcmol\/L\uff1b \u5c0f\u9f20\u7ecf\u53e3\u7684DNA\u6291\u5236\uff1a200 mg\/kg\uff1b 4.\u6025\u6027\u6bd2\u6027 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[19],"tags":[547,1231],"_links":{"self":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/posts\/3755"}],"collection":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/comments?post=3755"}],"version-history":[{"count":0,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/posts\/3755\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/media?parent=3755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/categories?post=3755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/tags?post=3755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}