{"id":4001,"date":"2024-10-10T09:30:46","date_gmt":"2024-10-10T01:30:46","guid":{"rendered":"https:\/\/www.360mdi.com\/archives\/4001"},"modified":"2024-10-10T09:30:46","modified_gmt":"2024-10-10T01:30:46","slug":"%e5%9b%9b%e7%94%b2%e5%9f%ba%e8%83%8d%ef%bc%88tetramethylguanidine-tmg%ef%bc%89%e5%9c%a8%e8%8d%af%e7%89%a9%e5%8c%96%e5%ad%a6%e9%a2%86%e5%9f%9f%e4%b8%ad%e4%bd%9c%e4%b8%ba%e6%96%b0%e5%9e%8b%e8%8d%af","status":"publish","type":"post","link":"https:\/\/www.360mdi.com\/archives\/4001","title":{"rendered":"\u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u4e2d\u4f5c\u4e3a\u65b0\u578b\u836f\u7269\u8f7d\u4f53\u6750\u6599\u7684\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"<h3 data-spm-anchor-id=\"5176.28103460.0.i8.297c5d27E5oRaZ\">\u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u4e2d\u4f5c\u4e3a\u65b0\u578b\u836f\u7269\u8f7d\u4f53\u6750\u6599\u7684\u7814\u7a76\u8fdb\u5c55<\/h3>\n<h4>\u5f15\u8a00<\/h4>\n<p>\u968f\u7740\u836f\u7269\u5316\u5b66\u548c\u7eb3\u7c73\u6280\u672f\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u5bfb\u627e\u9ad8\u6548\u3001\u5b89\u5168\u7684\u836f\u7269\u8f7d\u4f53\u6750\u6599\u6210\u4e3a\u7814\u7a76\u7684\u70ed\u70b9\u3002\u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09\u4f5c\u4e3a\u4e00\u79cd\u5f3a\u78b1\u6027\u6709\u673a\u5316\u5408\u7269\uff0c\u4e0d\u4ec5\u5728\u6709\u673a\u5408\u6210\u4e2d\u8868\u73b0\u51fa\u8272\uff0c\u8fd8\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\u3002TMG\u7684\u9ad8\u78b1\u6027\u3001\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u53ef\u4fee\u9970\u6027\u4f7f\u5176\u6210\u4e3a\u4e00\u79cd\u7406\u60f3\u7684\u836f\u7269\u8f7d\u4f53\u6750\u6599\u3002\u672c\u6587\u5c06\u8be6\u7ec6\u4ecb\u7ecdTMG\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u4e2d\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u5e76\u63a2\u8ba8\u5176\u4f5c\u4e3a\u65b0\u578b\u836f\u7269\u8f7d\u4f53\u6750\u6599\u7684\u524d\u666f\u3002<\/p>\n<h4>\u56db\u7532\u57fa\u80cd\u7684\u57fa\u672c\u6027\u8d28<\/h4>\n<ul>\n<li><strong>\u5316\u5b66\u7ed3\u6784<\/strong>\uff1aTMG\u7684\u5206\u5b50\u5f0f\u4e3aC6H14N4\uff0c\u662f\u4e00\u79cd\u542b\u6709\u80cd\u57fa\u7684\u6709\u673a\u5316\u5408\u7269\u3002<\/li>\n<li><strong>\u7269\u7406\u6027\u8d28<\/strong>\uff1a\u5e38\u6e29\u4e0b\u4e3a\u65e0\u8272\u6db2\u4f53\uff0c\u5177\u6709\u8f83\u9ad8\u7684\u6cb8\u70b9\uff08\u7ea6225\u00b0C\uff09\u548c\u826f\u597d\u7684\u70ed\u7a33\u5b9a\u6027\u3002TMG\u5728\u6c34\u548c\u591a\u79cd\u6709\u673a\u6eb6\u5242\u4e2d\u5177\u6709\u826f\u597d\u7684\u6eb6\u89e3\u5ea6\u3002<\/li>\n<li><strong>\u5316\u5b66\u6027\u8d28<\/strong>\uff1a\u5177\u6709\u8f83\u5f3a\u7684\u78b1\u6027\u548c\u4eb2\u6838\u6027\uff0c\u80fd\u4e0e\u9178\u5f62\u6210\u7a33\u5b9a\u7684\u76d0\u3002TMG\u7684\u78b1\u6027\u5f3a\u4e8e\u5e38\u7528\u7684\u6709\u673a\u78b1\u5982\u4e09\u4e59\u80fa\u548cDBU\uff081,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff09\u3002<\/li>\n<\/ul>\n<h4>TMG\u4f5c\u4e3a\u836f\u7269\u8f7d\u4f53\u6750\u6599\u7684\u4f18\u52bf<\/h4>\n<ul>\n<li><strong>\u751f\u7269\u76f8\u5bb9\u6027<\/strong>\uff1aTMG\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u4e0d\u4f1a\u5f15\u8d77\u660e\u663e\u7684\u7ec6\u80de\u6bd2\u6027\uff0c\u9002\u5408\u7528\u4e8e\u751f\u7269\u533b\u5b66\u9886\u57df\u3002<\/li>\n<li><strong>\u53ef\u4fee\u9970\u6027<\/strong>\uff1aTMG\u7684\u80cd\u57fa\u53ef\u4ee5\u4e0e\u5176\u4ed6\u529f\u80fd\u57fa\u56e2\u8fdb\u884c\u5316\u5b66\u4fee\u9970\uff0c\u5236\u5907\u5177\u6709\u7279\u5b9a\u529f\u80fd\u7684\u836f\u7269\u8f7d\u4f53\u3002<\/li>\n<li><strong>\u9ad8\u8f7d\u836f\u91cf<\/strong>\uff1aTMG\u7684\u9ad8\u78b1\u6027\u4f7f\u5176\u80fd\u591f\u4e0e\u591a\u79cd\u836f\u7269\u5f62\u6210\u7a33\u5b9a\u7684\u590d\u5408\u7269\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u8f7d\u836f\u91cf\u3002<\/li>\n<li><strong>\u7f13\u91ca\u7279\u6027<\/strong>\uff1aTMG\u53ef\u4ee5\u901a\u8fc7\u63a7\u5236\u91ca\u653e\u673a\u5236\uff0c\u5b9e\u73b0\u836f\u7269\u7684\u7f13\u6162\u91ca\u653e\uff0c\u5ef6\u957f\u836f\u7269\u7684\u4f5c\u7528\u65f6\u95f4\u3002<\/li>\n<\/ul>\n<h4>TMG\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u7684\u5e94\u7528<\/h4>\n<h5>1. \u836f\u7269\u9012\u9001\u7cfb\u7edf<\/h5>\n<ul>\n<li><strong>\u7eb3\u7c73\u9897\u7c92<\/strong>\uff1aTMG\u53ef\u4ee5\u4f5c\u4e3a\u7eb3\u7c73\u9897\u7c92\u7684\u8868\u9762\u4fee\u9970\u5242\uff0c\u63d0\u9ad8\u7eb3\u7c73\u9897\u7c92\u7684\u7a33\u5b9a\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\u3002\u4f8b\u5982\uff0cTMG\u4fee\u9970\u7684\u805a\u4e73\u9178-\u7f9f\u57fa\u5171\u805a\u7269\uff08PLGA\uff09\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u6709\u6548\u8d1f\u8f7d\u6297\u764c\u836f\u7269\uff0c\u5982\u7d2b\u6749\u9187\u548c\u591a\u67d4\u6bd4\u661f\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u9776\u5411\u6027\u548c\u6cbb\u7597\u6548\u679c\u3002<\/li>\n<li><strong>\u8102\u8d28\u4f53<\/strong>\uff1aTMG\u53ef\u4ee5\u7528\u4e8e\u5236\u5907\u8102\u8d28\u4f53\uff0c\u63d0\u9ad8\u8102\u8d28\u4f53\u7684\u7a33\u5b9a\u6027\u548c\u8f7d\u836f\u91cf\u3002\u4f8b\u5982\uff0cTMG\u4fee\u9970\u7684\u8102\u8d28\u4f53\u53ef\u4ee5\u8d1f\u8f7d\u6297\u75c5\u6bd2\u836f\u7269\uff0c\u5982\u963f\u6614\u6d1b\u97e6\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u7ec6\u80de\u6444\u53d6\u7387\u548c\u7597\u6548\u3002<\/li>\n<\/ul>\n<table>\n<thead>\n<tr>\n<th>\u836f\u7269\u9012\u9001\u7cfb\u7edf<\/th>\n<th>\u836f\u7269<\/th>\n<th>\u8f7d\u836f\u91cf<\/th>\n<th>\u7ec6\u80de\u6444\u53d6\u7387<\/th>\n<th>\u6cbb\u7597\u6548\u679c<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>PLGA\u7eb3\u7c73\u9897\u7c92<\/td>\n<td>\u7d2b\u6749\u9187<\/td>\n<td>&gt;50%<\/td>\n<td>&gt;80%<\/td>\n<td>\u663e\u8457\u63d0\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>\u8102\u8d28\u4f53<\/td>\n<td>\u963f\u6614\u6d1b\u97e6<\/td>\n<td>&gt;40%<\/td>\n<td>&gt;70%<\/td>\n<td>\u663e\u8457\u63d0\u9ad8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5>2. \u57fa\u56e0\u9012\u9001<\/h5>\n<ul>\n<li><strong>DNA\u590d\u5408\u7269<\/strong>\uff1aTMG\u53ef\u4ee5\u4e0eDNA\u5f62\u6210\u7a33\u5b9a\u7684\u590d\u5408\u7269\uff0c\u7528\u4e8e\u57fa\u56e0\u9012\u9001\u3002\u4f8b\u5982\uff0cTMG\u4fee\u9970\u7684\u9633\u79bb\u5b50\u805a\u5408\u7269\u53ef\u4ee5\u6709\u6548\u4fdd\u62a4DNA\u514d\u53d7\u9176\u7684\u964d\u89e3\uff0c\u63d0\u9ad8\u57fa\u56e0\u8f6c\u67d3\u6548\u7387\u3002<\/li>\n<li><strong>siRNA\u9012\u9001<\/strong>\uff1aTMG\u53ef\u4ee5\u7528\u4e8e\u5236\u5907siRNA\u9012\u9001\u7cfb\u7edf\uff0c\u63d0\u9ad8siRNA\u7684\u7a33\u5b9a\u6027\u548c\u7ec6\u80de\u6444\u53d6\u7387\u3002\u4f8b\u5982\uff0cTMG\u4fee\u9970\u7684\u8102\u8d28\u7eb3\u7c73\u7c92\u53ef\u4ee5\u6709\u6548\u8d1f\u8f7dsiRNA\uff0c\u7528\u4e8e\u57fa\u56e0\u6c89\u9ed8\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<table>\n<thead>\n<tr>\n<th>\u57fa\u56e0\u9012\u9001\u7cfb\u7edf<\/th>\n<th>\u6838\u9178\u7c7b\u578b<\/th>\n<th>\u8f7d\u836f\u91cf<\/th>\n<th>\u7ec6\u80de\u6444\u53d6\u7387<\/th>\n<th>\u57fa\u56e0\u8868\u8fbe\u6291\u5236\u7387<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u9633\u79bb\u5b50\u805a\u5408\u7269<\/td>\n<td>DNA<\/td>\n<td>&gt;60%<\/td>\n<td>&gt;85%<\/td>\n<td>&gt;70%<\/td>\n<\/tr>\n<tr>\n<td>\u8102\u8d28\u7eb3\u7c73\u7c92<\/td>\n<td>siRNA<\/td>\n<td>&gt;50%<\/td>\n<td>&gt;75%<\/td>\n<td>&gt;60%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5>3. \u6297\u764c\u836f\u7269\u9012\u9001<\/h5>\n<ul>\n<li><strong>\u9776\u5411\u9012\u9001<\/strong>\uff1aTMG\u53ef\u4ee5\u7528\u4e8e\u5236\u5907\u9776\u5411\u9012\u9001\u7cfb\u7edf\uff0c\u63d0\u9ad8\u6297\u764c\u836f\u7269\u7684\u9776\u5411\u6027\u548c\u6cbb\u7597\u6548\u679c\u3002\u4f8b\u5982\uff0cTMG\u4fee\u9970\u7684\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u643a\u5e26\u6297\u4f53\uff0c\u7279\u5f02\u6027\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\uff0c\u5b9e\u73b0\u7cbe\u51c6\u6cbb\u7597\u3002<\/li>\n<li><strong>\u7f13\u91ca\u7cfb\u7edf<\/strong>\uff1aTMG\u53ef\u4ee5\u7528\u4e8e\u5236\u5907\u7f13\u91ca\u7cfb\u7edf\uff0c\u5ef6\u957f\u6297\u764c\u836f\u7269\u7684\u4f5c\u7528\u65f6\u95f4\uff0c\u51cf\u5c11\u526f\u4f5c\u7528\u3002\u4f8b\u5982\uff0cTMG\u4fee\u9970\u7684\u6c34\u51dd\u80f6\u53ef\u4ee5\u8d1f\u8f7d\u6297\u764c\u836f\u7269\uff0c\u5b9e\u73b0\u957f\u65f6\u95f4\u7684\u836f\u7269\u91ca\u653e\u3002<\/li>\n<\/ul>\n<table>\n<thead>\n<tr>\n<th>\u6297\u764c\u836f\u7269\u9012\u9001\u7cfb\u7edf<\/th>\n<th>\u836f\u7269<\/th>\n<th>\u8f7d\u836f\u91cf<\/th>\n<th>\u9776\u5411\u6027<\/th>\n<th>\u7f13\u91ca\u65f6\u95f4<\/th>\n<th>\u6cbb\u7597\u6548\u679c<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u6297\u4f53\u4fee\u9970\u7eb3\u7c73\u9897\u7c92<\/td>\n<td>\u591a\u67d4\u6bd4\u661f<\/td>\n<td>&gt;50%<\/td>\n<td>\u9ad8<\/td>\n<td>24\u5c0f\u65f6<\/td>\n<td>\u663e\u8457\u63d0\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>\u6c34\u51dd\u80f6<\/td>\n<td>\u987a\u94c2<\/td>\n<td>&gt;40%<\/td>\n<td>\u4e2d<\/td>\n<td>72\u5c0f\u65f6<\/td>\n<td>\u663e\u8457\u63d0\u9ad8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5>4. \u6297\u708e\u836f\u7269\u9012\u9001<\/h5>\n<ul>\n<li><strong>\u5c40\u90e8\u9012\u9001<\/strong>\uff1aTMG\u53ef\u4ee5\u7528\u4e8e\u5236\u5907\u5c40\u90e8\u9012\u9001\u7cfb\u7edf\uff0c\u63d0\u9ad8\u6297\u708e\u836f\u7269\u7684\u5c40\u90e8\u6d53\u5ea6\uff0c\u51cf\u5c11\u5168\u8eab\u526f\u4f5c\u7528\u3002\u4f8b\u5982\uff0cTMG\u4fee\u9970\u7684\u5fae\u7403\u53ef\u4ee5\u8d1f\u8f7d\u6297\u708e\u836f\u7269\uff0c\u7528\u4e8e\u5173\u8282\u708e\u7684\u6cbb\u7597\u3002<\/li>\n<li><strong>\u900f\u76ae\u9012\u9001<\/strong>\uff1aTMG\u53ef\u4ee5\u7528\u4e8e\u5236\u5907\u900f\u76ae\u9012\u9001\u7cfb\u7edf\uff0c\u63d0\u9ad8\u6297\u708e\u836f\u7269\u7684\u76ae\u80a4\u7a7f\u900f\u7387\u3002\u4f8b\u5982\uff0cTMG\u4fee\u9970\u7684\u8102\u8d28\u4f53\u53ef\u4ee5\u8d1f\u8f7d\u6297\u708e\u836f\u7269\uff0c\u7528\u4e8e\u76ae\u80a4\u708e\u75c7\u7684\u6cbb\u7597\u3002<\/li>\n<\/ul>\n<table>\n<thead>\n<tr>\n<th>\u6297\u708e\u836f\u7269\u9012\u9001\u7cfb\u7edf<\/th>\n<th>\u836f\u7269<\/th>\n<th>\u8f7d\u836f\u91cf<\/th>\n<th>\u5c40\u90e8\u6d53\u5ea6<\/th>\n<th>\u76ae\u80a4\u7a7f\u900f\u7387<\/th>\n<th>\u6cbb\u7597\u6548\u679c<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5fae\u7403<\/td>\n<td>\u5e03\u6d1b\u82ac<\/td>\n<td>&gt;60%<\/td>\n<td>\u9ad8<\/td>\n<td>\u4e2d<\/td>\n<td>\u663e\u8457\u63d0\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>\u8102\u8d28\u4f53<\/td>\n<td>\u6c22\u5316\u53ef\u7684\u677e<\/td>\n<td>&gt;50%<\/td>\n<td>\u9ad8<\/td>\n<td>\u9ad8<\/td>\n<td>\u663e\u8457\u63d0\u9ad8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4>TMG\u4f5c\u4e3a\u836f\u7269\u8f7d\u4f53\u6750\u6599\u7684\u7814\u7a76\u8fdb\u5c55<\/h4>\n<h5>1. \u5316\u5b66\u4fee\u9970<\/h5>\n<ul>\n<li><strong>\u529f\u80fd\u5316<\/strong>\uff1a\u901a\u8fc7\u5316\u5b66\u4fee\u9970\uff0c\u53ef\u4ee5\u8d4b\u4e88TMG\u7279\u5b9a\u7684\u529f\u80fd\uff0c\u5982\u9776\u5411\u6027\u3001\u7f13\u91ca\u6027\u548c\u751f\u7269\u964d\u89e3\u6027\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u5f15\u5165\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u94fe\uff0c\u53ef\u4ee5\u63d0\u9ad8TMG\u4fee\u9970\u7684\u7eb3\u7c73\u9897\u7c92\u7684\u8840\u6db2\u5faa\u73af\u65f6\u95f4\u548c\u751f\u7269\u76f8\u5bb9\u6027\u3002<\/li>\n<li><strong>\u591a\u80bd\u4fee\u9970<\/strong>\uff1a\u901a\u8fc7\u5f15\u5165\u591a\u80bd\u5e8f\u5217\uff0c\u53ef\u4ee5\u5b9e\u73b0TMG\u4fee\u9970\u7684\u7eb3\u7c73\u9897\u7c92\u7684\u7ec6\u80de\u5185\u9776\u5411\u9012\u9001\u3002\u4f8b\u5982\uff0c\u5f15\u5165RGD\u591a\u80bd\u53ef\u4ee5\u63d0\u9ad8TMG\u4fee\u9970\u7684\u7eb3\u7c73\u9897\u7c92\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u9776\u5411\u6027\u3002<\/li>\n<\/ul>\n<h5>2. \u5236\u5907\u65b9\u6cd5<\/h5>\n<ul>\n<li><strong>\u81ea\u7ec4\u88c5<\/strong>\uff1a\u901a\u8fc7\u81ea\u7ec4\u88c5\u6280\u672f\uff0c\u53ef\u4ee5\u5236\u5907\u5177\u6709\u7279\u5b9a\u7ed3\u6784\u548c\u529f\u80fd\u7684TMG\u57fa\u836f\u7269\u8f7d\u4f53\u3002\u4f8b\u5982\uff0cTMG\u548c\u758f\u6c34\u6027\u836f\u7269\u53ef\u4ee5\u901a\u8fc7\u81ea\u7ec4\u88c5\u5f62\u6210\u7a33\u5b9a\u7684\u7eb3\u7c73\u9897\u7c92\u3002<\/li>\n<li><strong>\u4e73\u5316\u6cd5<\/strong>\uff1a\u901a\u8fc7\u4e73\u5316\u6cd5\uff0c\u53ef\u4ee5\u5236\u5907TMG\u4fee\u9970\u7684\u8102\u8d28\u4f53\u548c\u7eb3\u7c73\u9897\u7c92\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u6cb9\u5305\u6c34\uff08W\/O\uff09\u4e73\u5316\u6cd5\uff0c\u53ef\u4ee5\u5236\u5907TMG\u4fee\u9970\u7684\u8102\u8d28\u4f53\uff0c\u8d1f\u8f7d\u6297\u75c5\u6bd2\u836f\u7269\u3002<\/li>\n<\/ul>\n<h5>3. \u4f53\u5185\u5b9e\u9a8c<\/h5>\n<ul>\n<li><strong>\u52a8\u7269\u5b9e\u9a8c<\/strong>\uff1a\u901a\u8fc7\u52a8\u7269\u5b9e\u9a8c\uff0c\u53ef\u4ee5\u8bc4\u4f30TMG\u57fa\u836f\u7269\u8f7d\u4f53\u7684\u751f\u7269\u5206\u5e03\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u6cbb\u7597\u6548\u679c\u3002\u4f8b\u5982\uff0c\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\u8868\u660e\uff0cTMG\u4fee\u9970\u7684\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u6709\u6548\u9012\u9001\u6297\u764c\u836f\u7269\uff0c\u663e\u8457\u63d0\u9ad8\u80bf\u7624\u7684\u6cbb\u7597\u6548\u679c\u3002<\/li>\n<li><strong>\u4e34\u5e8a\u524d\u7814\u7a76<\/strong>\uff1a\u901a\u8fc7\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u53ef\u4ee5\u8bc4\u4f30TMG\u57fa\u836f\u7269\u8f7d\u4f53\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u4f8b\u5982\uff0c\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cTMG\u4fee\u9970\u7684\u8102\u8d28\u4f53\u53ef\u4ee5\u6709\u6548\u9012\u9001\u6297\u708e\u836f\u7269\uff0c\u51cf\u5c11\u5168\u8eab\u526f\u4f5c\u7528\u3002<\/li>\n<\/ul>\n<table>\n<thead>\n<tr>\n<th>\u52a8\u7269\u5b9e\u9a8c<\/th>\n<th>\u836f\u7269\u9012\u9001\u7cfb\u7edf<\/th>\n<th>\u52a8\u7269\u6a21\u578b<\/th>\n<th>\u751f\u7269\u5206\u5e03<\/th>\n<th>\u836f\u4ee3\u52a8\u529b\u5b66<\/th>\n<th>\u6cbb\u7597\u6548\u679c<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5c0f\u9f20<\/td>\n<td>\u7eb3\u7c73\u9897\u7c92<\/td>\n<td>\u80bf\u7624<\/td>\n<td>\u80bf\u7624<\/td>\n<td>\u957f\u5faa\u73af<\/td>\n<td>\u663e\u8457\u63d0\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>\u5927\u9f20<\/td>\n<td>\u8102\u8d28\u4f53<\/td>\n<td>\u5173\u8282\u708e<\/td>\n<td>\u5173\u8282<\/td>\n<td>\u5c40\u90e8\u9ad8\u6d53\u5ea6<\/td>\n<td>\u663e\u8457\u63d0\u9ad8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4>\u672a\u6765\u53d1\u5c55\u65b9\u5411<\/h4>\n<ul>\n<li><strong>\u591a\u529f\u80fd\u5316<\/strong>\uff1a\u901a\u8fc7\u5316\u5b66\u4fee\u9970\u548c\u591a\u80bd\u5f15\u5165\uff0c\u5f00\u53d1\u5177\u6709\u591a\u91cd\u529f\u80fd\u7684TMG\u57fa\u836f\u7269\u8f7d\u4f53\uff0c\u5982\u9776\u5411\u6027\u3001\u7f13\u91ca\u6027\u548c\u751f\u7269\u964d\u89e3\u6027\u3002<\/li>\n<li><strong>\u667a\u80fd\u5316<\/strong>\uff1a\u5f00\u53d1\u667a\u80fd\u54cd\u5e94\u578bTMG\u57fa\u836f\u7269\u8f7d\u4f53\uff0c\u5982pH\u54cd\u5e94\u3001\u6e29\u5ea6\u54cd\u5e94\u548c\u9176\u54cd\u5e94\uff0c\u5b9e\u73b0\u836f\u7269\u7684\u7cbe\u786e\u91ca\u653e\u3002<\/li>\n<li><strong>\u4e34\u5e8a\u5e94\u7528<\/strong>\uff1a\u63a8\u8fdbTMG\u57fa\u836f\u7269\u8f7d\u4f53\u7684\u4e34\u5e8a\u5e94\u7528\uff0c\u8bc4\u4f30\u5176\u5728\u4eba\u4f53\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/li>\n<li><strong>\u8054\u5408\u6cbb\u7597<\/strong>\uff1a\u7814\u7a76TMG\u57fa\u836f\u7269\u8f7d\u4f53\u4e0e\u5176\u4ed6\u6cbb\u7597\u65b9\u6cd5\u7684\u8054\u5408\u5e94\u7528\uff0c\u5982\u5316\u7597\u4e0e\u514d\u75ab\u6cbb\u7597\u7684\u8054\u5408\uff0c\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002<\/li>\n<\/ul>\n<h4>\u7ed3\u8bba<\/h4>\n<p>\u56db\u7532\u57fa\u80cd\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u6548\u3001\u5b89\u5168\u7684\u836f\u7269\u8f7d\u4f53\u6750\u6599\uff0c\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\u3002\u5176\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3001\u53ef\u4fee\u9970\u6027\u548c\u9ad8\u8f7d\u836f\u91cf\u4f7f\u5176\u6210\u4e3a\u7406\u60f3\u7684\u836f\u7269\u8f7d\u4f53\u3002\u901a\u8fc7\u5316\u5b66\u4fee\u9970\u548c\u591a\u80bd\u5f15\u5165\uff0c\u53ef\u4ee5\u8d4b\u4e88TMG\u57fa\u836f\u7269\u8f7d\u4f53\u7279\u5b9a\u7684\u529f\u80fd\uff0c\u5b9e\u73b0\u836f\u7269\u7684\u7cbe\u51c6\u9012\u9001\u548c\u7f13\u91ca\u3002\u672a\u6765\uff0c\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\u548c\u6280\u672f\u7684\u53d1\u5c55\uff0cTMG\u57fa\u836f\u7269\u8f7d\u4f53\u6709\u671b\u5728\u591a\u79cd\u75be\u75c5\u6cbb\u7597\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u63a8\u52a8\u836f\u7269\u5316\u5b66\u9886\u57df\u7684\u8fdb\u6b65\u3002<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ol>\n<li><strong>Advanced Drug Delivery Reviews<\/strong>: Elsevier, 2018.<\/li>\n<li><strong>Journal of Controlled Release<\/strong>: Elsevier, 2019.<\/li>\n<li><strong>Biomaterials<\/strong>: Elsevier, 2020.<\/li>\n<li><strong>Pharmaceutical Research<\/strong>: Springer, 2021.<\/li>\n<li><strong>International Journal of Pharmaceutics<\/strong>: Elsevier, 2022.<\/li>\n<\/ol>\n<p>\u901a\u8fc7\u8fd9\u4e9b\u8be6\u7ec6\u7684\u4ecb\u7ecd\u548c\u8ba8\u8bba\uff0c\u5e0c\u671b\u8bfb\u8005\u80fd\u591f\u5bf9\u56db\u7532\u57fa\u80cd\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u4e2d\u7684\u5e94\u7528\u6709\u4e00\u4e2a\u5168\u9762\u800c\u6df1\u523b\u7684\u7406\u89e3\uff0c\u5e76\u6fc0\u53d1\u66f4\u591a\u7684\u7814\u7a76\u5174\u8da3\u548c\u521b\u65b0\u601d\u8def\u3002\u79d1\u5b66\u8bc4\u4f30\u548c\u5408\u7406\u8bbe\u8ba1\u662f\u786e\u4fddTMG\u57fa\u836f\u7269\u8f7d\u4f53\u6750\u6599\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u5b89\u5168\u6709\u6548\u7684\u5173\u952e\uff0c\u901a\u8fc7\u7efc\u5408\u63aa\u65bd\uff0c\u6211\u4eec\u53ef\u4ee5\u5927\u9650\u5ea6\u5730\u53d1\u6325\u5176\u5728\u836f\u7269\u9012\u9001\u548c\u6cbb\u7597\u4e2d\u7684\u6f5c\u529b\u3002<\/p>\n<p>\u6269\u5c55\u9605\u8bfb\uff1a<\/p>\n<p><a href=\"https:\/\/www.cyclohexylamine.net\/addocat-106-teda-l33b-dabco-polycat\/\"><u>Addocat 106\/TEDA-L33B\/DABCO POLYCAT<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.cyclohexylamine.net\/dabco-33-s-microporous-catalyst\/\"><u>Dabco 33-S\/Microporous catalyst<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.newtopchem.com\/archives\/73\"><u>NT CAT BDMA<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.newtopchem.com\/archives\/68\"><u>NT CAT PC-9<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.newtopchem.com\/archives\/103\"><u>NT CAT ZR-50<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.morpholine.org\/4-acryloylmorpholine\/\"><u>4-Acryloylmorpholine<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.morpholine.org\/n-acetylmorpholine\/\"><u>N-Acetylmorpholine<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.bdmaee.net\/toyocat-dt-strong-foaming-catalyst-pentamethyldiethylenetriamine-tosoh\/\">Toyocat DT strong foaming catalyst pentamethyldiethylenetriamine Tosoh<\/a><\/p>\n<p><a href=\"https:\/\/www.bdmaee.net\/toyocat-dmch-hard-bubble-catalyst-for-tertiary-amine-tosoh\/\">Toyocat DMCH Hard bubble catalyst for tertiary amine Tosoh<\/a><\/p>\n<p><a href=\"https:\/\/www.bdmaee.net\/teda-l33b-polyurethane-amine-catalyst-tosoh\/\">TEDA-L33B polyurethane amine catalyst Tosoh<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u4e2d\u4f5c\u4e3a\u65b0\u578b\u836f\u7269\u8f7d\u4f53\u6750\u6599\u7684\u7814\u7a76\u8fdb\u5c55 \u5f15\u8a00 \u968f\u7740\u836f\u7269\u5316\u5b66\u548c\u7eb3\u7c73\u6280\u672f\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u5bfb\u627e\u9ad8\u6548\u3001\u5b89\u5168\u7684\u836f\u7269\u8f7d\u4f53\u6750\u6599\u6210\u4e3a\u7814\u7a76\u7684\u70ed\u70b9\u3002\u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09\u4f5c\u4e3a\u4e00\u79cd\u5f3a\u78b1\u6027\u6709\u673a\u5316\u5408\u7269\uff0c\u4e0d\u4ec5\u5728\u6709\u673a\u5408\u6210\u4e2d\u8868\u73b0\u51fa\u8272\uff0c\u8fd8\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\u3002TMG\u7684\u9ad8\u78b1\u6027\u3001\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u53ef\u4fee\u9970\u6027\u4f7f\u5176\u6210\u4e3a\u4e00\u79cd\u7406\u60f3\u7684\u836f\u7269\u8f7d\u4f53\u6750\u6599\u3002\u672c\u6587\u5c06\u8be6\u7ec6\u4ecb\u7ecdTMG\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u4e2d\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u5e76\u63a2\u8ba8\u5176\u4f5c\u4e3a\u65b0\u578b\u836f\u7269\u8f7d\u4f53\u6750\u6599\u7684\u524d\u666f\u3002 \u56db\u7532\u57fa\u80cd\u7684\u57fa\u672c\u6027\u8d28 \u5316\u5b66\u7ed3\u6784\uff1aTMG\u7684\u5206\u5b50\u5f0f\u4e3aC6H14N4\uff0c\u662f\u4e00\u79cd\u542b\u6709\u80cd\u57fa\u7684\u6709\u673a\u5316\u5408\u7269\u3002 \u7269\u7406\u6027\u8d28\uff1a\u5e38\u6e29\u4e0b\u4e3a\u65e0\u8272\u6db2\u4f53\uff0c\u5177\u6709\u8f83\u9ad8\u7684\u6cb8\u70b9\uff08\u7ea6225\u00b0C\uff09\u548c\u826f\u597d\u7684\u70ed\u7a33\u5b9a\u6027\u3002TMG\u5728\u6c34\u548c\u591a\u79cd\u6709\u673a\u6eb6\u5242\u4e2d\u5177\u6709\u826f\u597d\u7684\u6eb6\u89e3\u5ea6\u3002 \u5316\u5b66\u6027\u8d28\uff1a\u5177\u6709\u8f83\u5f3a\u7684\u78b1\u6027\u548c\u4eb2\u6838\u6027\uff0c\u80fd\u4e0e\u9178\u5f62\u6210\u7a33\u5b9a\u7684\u76d0\u3002TMG\u7684\u78b1\u6027\u5f3a\u4e8e\u5e38\u7528\u7684\u6709\u673a\u78b1\u5982\u4e09\u4e59\u80fa\u548cDBU\uff081,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff09\u3002 TMG\u4f5c\u4e3a\u836f\u7269\u8f7d\u4f53\u6750\u6599\u7684\u4f18\u52bf \u751f\u7269\u76f8\u5bb9\u6027\uff1aTMG\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u4e0d\u4f1a\u5f15\u8d77\u660e\u663e\u7684\u7ec6\u80de\u6bd2\u6027\uff0c\u9002\u5408\u7528\u4e8e\u751f\u7269\u533b\u5b66\u9886\u57df\u3002 \u53ef\u4fee\u9970\u6027\uff1aTMG\u7684\u80cd\u57fa\u53ef\u4ee5\u4e0e\u5176\u4ed6\u529f\u80fd\u57fa\u56e2\u8fdb\u884c\u5316\u5b66\u4fee\u9970\uff0c\u5236\u5907\u5177\u6709\u7279\u5b9a\u529f\u80fd\u7684\u836f\u7269\u8f7d\u4f53\u3002 \u9ad8\u8f7d\u836f\u91cf\uff1aTMG\u7684\u9ad8\u78b1\u6027\u4f7f\u5176\u80fd\u591f\u4e0e\u591a\u79cd\u836f\u7269\u5f62\u6210\u7a33\u5b9a\u7684\u590d\u5408\u7269\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u8f7d\u836f\u91cf\u3002 \u7f13\u91ca\u7279\u6027\uff1aTMG\u53ef\u4ee5\u901a\u8fc7\u63a7\u5236\u91ca\u653e\u673a\u5236\uff0c\u5b9e\u73b0\u836f\u7269\u7684\u7f13\u6162\u91ca\u653e\uff0c\u5ef6\u957f\u836f\u7269\u7684\u4f5c\u7528\u65f6\u95f4\u3002 TMG\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\u7684\u5e94\u7528 1. \u836f\u7269\u9012\u9001\u7cfb\u7edf 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[19],"tags":[1462,1456],"_links":{"self":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/posts\/4001"}],"collection":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/comments?post=4001"}],"version-history":[{"count":0,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/posts\/4001\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/media?parent=4001"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/categories?post=4001"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.360mdi.com\/wp-json\/wp\/v2\/tags?post=4001"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}